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Tag search: "CRISPR"

Promoting health through the life course

CRISPR pioneer Jennifer Doudna on gene editing’s potential for good and evil

CRISPR gives scientists the power to radically and irreversibly alter the biosphere by providing a way to rewrite the very molecules of life any way we wish. There needs to be more discussions of the possibilities it presents for good and for ill. However, even though it is still a thrilling moment for life sciences, we all have a responsibility to consider any ramifications in advance and engage in an inclusive conversation about how to harness gene editing in a natural world context

June 20, 2017
Fast Company

Non communicable diseases

Report: Scientists edit human embryos for first time in US

America reportedly has moved ahead in a controversial race to tinker with human DNA -- but the scientific feat is shrouded in unanswered questions. The MIT Technology Review published a news report about the first-known experiment to create genetically modified human embryos in the United States using a gene-editing tool called CRISPR. "Results of the peer-reviewed study are expected to be published soon in a scientific journal. No further information will be provided before then," according to a statement from the university`s press office

July 28, 2017
CNN
July 26, 2017
Stat News

Gene-editing technique scientists hope will cure cancer and all inherited disease found to have ...

Researchers writing in the journal Nature Methods described how they had used Crispr-Cas9 to restore sight to blind mice. However, when they sequenced the entire genome of the animals, they found two had more than 1,500 small mutations and more than 100 larger deletions and insertions of genetic material. The researchers said they hope the findings will encourage others to use whole-genome sequencing as a method to determine all the off-target effects of Crispr techniques and study different versions for the safest, most accurate form of editing

May 29, 2017
The Independent

Fast CRISPR test easily detects Zika and antibiotic resistance

The system that sparked a revolution in gene editing can also be used in fast and cheap tests for pathogens. A tool based on CRISPR has been shown to detect the Zika virus in blood, urine and saliva, but could also be used for understanding cancer. It was developed by researchers at the Broad Institute in Massachusetts, who call it SHERLOCK – for Specific High Sensitivity Enzymatic Reporter Unlocking. The team say the system can detect single molecules of genetic material among mixed samples and can distinguish between genetic sequences that differ by only one letter

April 13, 2017
New Scientist, Eureka Alert
April 14, 2017
Business Standard
April 13, 2017
Phys.Org, Washington Post

Betting on the first disease to be treated by gene editing

Anticipating when CRISPR gene editing technology could be used to develop a cure for a myriad of possible diseases is difficult to assess. There are not only technical hurdles, but also ethical ones – such as gene editing in embryos to prevent diseases such as Huntington’s and Tay-Sachs. Even so, the race is on CNBC reports

March 15, 2017
CNBC

Communicable diseases

Smart insects put a fly in the gene-editing ointment

A new study, by Michael Wade and Gabriel Zentner, from Indiana University, studied the flour beetle and focused on three stretches of the beetle’s genome where CRISPR technology could potentially snip out or insert genes. Two targets were chosen for their links to male and female fertility. The third because it mirrors a pot in the mosquito genome previously scouted as a potential anti-malarial target. They discovered there was sufficient natural variation in the flour beetles to get rid of any CRISPR i tampering in just six generations. Not only that, subsequent generations favoured genes that circumvented the CRISPR intervention, even if they were rare ones

May 22, 2017
Financial Times

CRISPR Eliminates HIV in Live Animals

A new study released by a team of researchers at Lewis Katz School of Medicine and the University of Pittsburgh shows that HIV DNA can be exised from the genomes of living animals to eliminate further infection. The researchers achieved this with three different animal models, including a ‘humanized’ model in which mice were transplanted with human immune cells and infected with the virus. The study shows that HIV-1 replication can be shut down and the virus eliminated with a powerful gene-editing technology known as CRISPR/Cas9

May 2, 2017
Genetic Engineering News, Huffington Post, zeenews, UPI