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Tag search: "Cholesterol"

Non communicable diseases

SGLT2 inhibitors help reduce high blood pressure, study reports

A group of oral medications given to people with type 2 diabetes have been found to help reduce high blood pressure. A research team from China, South Africa and Iran looked at 43 random trials which had involved 22,428 people. As well as high blood pressure, they examined how SGLT2 inhibitors affected health markers including cholesterol and triglycerides. SGLT2 inhibitor therapy was shown to significantly reduce blood pressure throughout the studies

July 7, 2017
Diabetes.co.uk

Anti-PCSK9 vaccine lowers cholesterol, atherosclerosis in mice

A study published in the European Heart Journal concludes that it may be possible to immunize people against developing high cholesterol and atherosclerosis, or the narrowing of the arteries. The vaccine, AT04A, consists of a molecule that prompts the body to produce antibodies against the enzyme. Once PCSK9 is inhibited, the body is able to properly clear LDL cholesterol. When the vaccine was injected in mice that were fed fatty food to induce high cholesterol and atherosclerosis, their total cholesterol fell 53%. Damage to blood vessels fell 64%, while blood vessel inflammation decreased by at least 21%, the scientists said

June 19, 2017
Fiercebiotech
June 20, 2017
UPI, Pharmazeutische Zeitung

Unique gene that staves off heart disease identified

Scientists have identified a unique gene variant in people living in isolated Greek villages that protects them from heart diseases despite enjoying a high-fat diet. The variant, rs145556679*, is associated with lower levels of both ‘bad’ natural fats and ‘bad’ cholesterol, the factors that lower the risk of cardiovascular disease, said researchers from Wellcome Trust Sanger Institute in the UK. The cardioprotective variant was found in Mylopotamos, northern Crete where the population is isolated and live a long life despite having a diet rich in animal fat

May 29, 2017
Indian Express, Hindustan Times, NDTV, Herald Scotland

Genetic mutations study validate new strategy for reducing cholesterol

According to a recent study, an injectable antibody can be really helpful for lowering blood lipids and thereby potentially preventing coronary artery disease and other conditions caused by the build-up of fats, cholesterol. This new study targets a protein called ANGPTL3, a regulator of enzymes that clears triglycerides and other fat molecules from the blood. The scientists studied ANGPTL3 in both humans and mice. They found that blocking ANGPTL3 activity with an investigative injectable antibody, known as evinacumab, reduced triglycerides by up to 76 percent and lowered LDL cholesterol 23 percent in human study participants and largely reversed signs of atherosclerosis in mouse models

May 29, 2017
Economic Times

Lack of sunlight could increase the risk of heart disease in obese children, study claims

A study of medical records of children aged six to 17 found many who were overweight and had high cholesterol and fatty acids and also suffered from low vitamin D. The researchers suggested that children with weight problems should spend more time out in the sun which stimulates the body to produce Vitamin D naturally

April 10, 2017
Irish Sun

Communicable diseases

New Cornell discovery could lead to effective treatment for tuberculosis

The mechanisms of how Mtb bacteria assimilate the host`s fatty acids have remained a mystery until now. Using a genetic screen, scientists identified genes involved in cholesterol metabolism. This identified the gene LucA. Further work determined that LucA interacts with subunits of specific proteins in the Mce1 and Mce4 complexes, which import fatty acids and cholesterol, respectively

July 7, 2017
News Medical