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Tag search: "Gene Editing"

Preparedness, surveillance and response

Vírus da febre amarela tem mutação genética inédita, diz Fiocruz…

The current yellow fever virus in Brazil has a built-in number of unprecedented genetic variations, according to researchers at the Oswaldo Cruz Institute. They detected eight possible mutations in the genetic sequence of the virus, seven of them associated with the viral replication mechanism. The Institute says that there is no previous record of such mutations in any world scientific literature

May 15, 2017
Noticias.uol.com, G1.Globo.com, Folha.uol.com, OGlobo, Veja Abril, Agencia Brasil

Non communicable diseases

Report: Scientists edit human embryos for first time in US

America reportedly has moved ahead in a controversial race to tinker with human DNA -- but the scientific feat is shrouded in unanswered questions. The MIT Technology Review published a news report about the first-known experiment to create genetically modified human embryos in the United States using a gene-editing tool called CRISPR. "Results of the peer-reviewed study are expected to be published soon in a scientific journal. No further information will be provided before then," according to a statement from the university`s press office

July 28, 2017
July 26, 2017
Stat News

Gene-editing technique scientists hope will cure cancer and all inherited disease found to have ...

Researchers writing in the journal Nature Methods described how they had used Crispr-Cas9 to restore sight to blind mice. However, when they sequenced the entire genome of the animals, they found two had more than 1,500 small mutations and more than 100 larger deletions and insertions of genetic material. The researchers said they hope the findings will encourage others to use whole-genome sequencing as a method to determine all the off-target effects of Crispr techniques and study different versions for the safest, most accurate form of editing

May 29, 2017
The Independent

Antibody genes influence forgotten heart disease

New research has found that genetic differences in antibody genes alter individuals’ susceptibility to rheumatic heart disease, an inflammatory condition known as RHD, that is rife in developing countries. The research is surprising and important as antibody genes have received little attention from those studying inflammatory or autoimmune disease, so it may have ramifications beyond heart disease

May 12, 2017
Medical Express

Fast CRISPR test easily detects Zika and antibiotic resistance

The system that sparked a revolution in gene editing can also be used in fast and cheap tests for pathogens. A tool based on CRISPR has been shown to detect the Zika virus in blood, urine and saliva, but could also be used for understanding cancer. It was developed by researchers at the Broad Institute in Massachusetts, who call it SHERLOCK – for Specific High Sensitivity Enzymatic Reporter Unlocking. The team say the system can detect single molecules of genetic material among mixed samples and can distinguish between genetic sequences that differ by only one letter

April 13, 2017
New Scientist, Eureka Alert
April 14, 2017
Business Standard
April 13, 2017
Phys.Org, Washington Post

Betting on the first disease to be treated by gene editing

Anticipating when CRISPR gene editing technology could be used to develop a cure for a myriad of possible diseases is difficult to assess. There are not only technical hurdles, but also ethical ones – such as gene editing in embryos to prevent diseases such as Huntington’s and Tay-Sachs. Even so, the race is on CNBC reports

March 15, 2017

Gene activity in the nose may signal lung cancer

Genetic changes in the cells lining the inside the nose might someday help doctors to diagnose lung cancer, a recent study suggests

March 7, 2017

Gene therapy relieves sickle cell in world first: study

Scientists have used gene therapy to relieve symptoms of a teenager suffering sickle cell disease in a world’s first breakthrough. The research team collected so-called haematopoietic stem cells from the bone marrow of the youngster, then aged 13. The immature cells were treated with a therapeutic gene, carried in a deactivated virus, which recoded the DNA to correct blood cell production. The treated cells were then reinjected into the boy’s body  

March 7, 2017
Japan Today

Gene Variants Linked To Fatal Gallbladder Cancer, New Study Finds

A recent study shows that some genetic variants are responsible for making certain individuals prone to develop gallbladder cancer. The study was carried out at around 700,000 varied locations of the genome in order to better understand the major cause of the fatal disease and to facilitate its treatment

March 6, 2017
Tech Times

Communicable diseases

Malaria genome study reveals savvy, finely tuned parasite

In a detailed study analysing more than half the genes in the genome of the parasite that cause malaria - Plasmodium - researchers found that two thirds of those genes are essential for survival. This is the largest proportion of essential genes found in any organism studied to date, they said. Importantly for researchers trying to develop vaccines and drugs against the disease, the scientists discovered that the parasite often disposes of genes that produce proteins that give its presence away to its host`s immune system. This allows malaria to swiftly change its appearance to the human immune system and hence build up resistance to a vaccine, posing problems for the development of effective shots

July 13, 2017

Liberação de mosquitos transgênicos contra dengue e zika avança no país

After the success in Piracicaba (São Paulo) with its transgenic Aedes aegypti mosquitoes, Oxitec is likely to release them to fly higher and further, perhaps even in other Brazilian states. Some of the potential cities that could receive the modified mosquito include Juiz de Fora (Minas Gerais) and Búzios (Río Janeiro)

June 9, 2017

Smart insects put a fly in the gene-editing ointment

A new study, by Michael Wade and Gabriel Zentner, from Indiana University, studied the flour beetle and focused on three stretches of the beetle’s genome where CRISPR technology could potentially snip out or insert genes. Two targets were chosen for their links to male and female fertility. The third because it mirrors a pot in the mosquito genome previously scouted as a potential anti-malarial target. They discovered there was sufficient natural variation in the flour beetles to get rid of any CRISPR i tampering in just six generations. Not only that, subsequent generations favoured genes that circumvented the CRISPR intervention, even if they were rare ones

May 22, 2017
Financial Times

Si no puedes con el mosquito, inféctalo

El Pais reported on the Medellin project to eliminate dengue by inoculating a bacterium into mosquitoes (wolbachia) which shortens mosquito lives. They are most infectious at their final stages in the life cycle, so this process cuts the risk of the mosquitoes transmitting dengue, yellow fever, Zika and chikungunya. Wolbachia is transmitted from mothers to children, so all the mosquito offspring are unable to transmit to humans. If a male is the carrier and the female is not, the eggs are infertile. This theory was put into successful practice in Australia and now experiments are beginning in Indonesia, Brazil and Colombia

May 3, 2017
El Pais, Tele Medellin

Latest breakthroughs point a way foward to eradicating malaria

Scientists from the Crick Institute and the Welcome Trust discovered a family of genes called pir determines how long malaria parasites persist in the human body. These parasites expressing the pir genes take over as the dominant parasite and establish a long lasting and persistent infection. This discovery opens the possibility that treatments targeting the pir genes could prevent persistent infection that causes chronic malaria. Studying the genomes of the parasites, scientists also found two genetic markers associated with piperaquine resistance. These markers can be used to monitor the spread of drug-resistant malaria

April 25, 2017
Financial Times